A Level Biology Practice Exam

What is the characteristic shape of cells observed in spherocytosis?

1. Spherical shape more than usual

2. Irregular shape

3. Elongated shape

4. Flattened shape

The correct answer is: Spherical shape more than usual

In spherocytosis, red blood cells exhibit a characteristic spherical shape that is more pronounced than normal. This condition, known as hereditary spherocytosis, results from a defect in the proteins that make up the red blood cell membrane, leading to a loss of the typical biconcave disk shape. The spherical shape of these cells makes them less flexible and more prone to rupture, contributing to hemolytic anemia associated with the condition. Other shapes, such as irregular, elongated, or flattened, do not accurately describe the typical morphology of red blood cells in spherocytosis. The distinct spherical shape is the primary identifying feature in diagnosing this disorder.